Large apical thrombus due to Takotsubo cardiomyopathy.

To cite: Wong GR, RobertsThomson R, Parvar SL, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2016-214503 DESCRIPTION A 55-year-old woman presented with chest pain following a high-speed motor vehicle accident. ECG revealed sinus rhythm with anterior lead ST depression. High-sensitivity troponin increased from baseline 58 to peak of 477 ng/L (normal <29 ng/L). Transthoracic echocardiogram demonstrated overall mildly impaired left ventricular (LV) function with mid to apical akinesis and preserved basal systolic function typical of Takotsubo cardiomyopathy. There was a large echogenic apical mass suspicious of an apical thrombus (figure 1). Coronary angiography found normal epicardial coronary arteries. Cardiovascular MRI (CMR) confirmed a large apical thrombus (20×10 mm) seen on both early and late gadolinium images. There was, however, no myocardial late gadolinium enhancement to indicate myocardial infarction (figure 2). LV findings on CMR were also typical for Takotsubo cardiomyopathy. The patient was started on therapeutic anticoagulation with warfarin and heart failure therapy with bisoprolol and perindopril. Follow-up imaging after 3 months showed complete resolution of the LV thrombus and recovery in systolic function (figure 2). Takotsubo cardiomyopathy is increasingly recognised in patients presenting with an acute coronary syndrome. An emotional, psychological or physical stressor is often present. Potential complications include acute pump failure, hypotension, pulmonary oedema and arrhythmia. The prevalence of LV thrombus in Takotsubo cardiomyopathy has been reported in a small case series as being up to 8% diagnosed on echocardiography. However, intracardiac thrombus may be under-recognised on echocardiography due to variable image quality, despite ultrasound contrast agents. CMR has been shown to have a superior sensitivity and specificity in the detection of thrombus, particularly on early gadolinium sequences. Short-term anticoagulation with heparin or warfarin has been successful in resolving intracardiac thrombus, although the duration of therapy is uncertain, and serial imaging is required to assess for thrombus resolution. At present, there is insufficient evidence to recommend the use of direct oral anticoagulants in this setting and there are no firm clinical guideline recommendations on anticoagulant therapy for the management of LV thrombus in Takotsubo cardiomyopathy. Prophylactic anticoagulation has been suggested, in a small systematic review, for female patients above 65 years of age and those at higher risk of thrombus formation with a large region of akinesis and elevated C reactive protein. These patients may benefit from more vigorous higher resolution imaging to assess for LV thrombus.